our technology

LineaRx provides large-scale production of DNA sequences using polymerase chain reaction (PCR). Scaling PCR for high volume delivers highly purified DNA, without the complications of plasmids, for use in cell therapies, vaccines, diagnostics and gene therapies. We can meet CRO and CMO needs with linear DNA at any scale.

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In the past 12 months, LineaRx has shipped over 8,000 milligrams of PCR-produced linear DNA for use in Diagnostic and Therapeutic applications. The Company has completed, or is progressing through, key milestones of a growing number of therapeutics research contracts for companies producing DNA and RNA vaccines and adoptive cell therapies.

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CRO/CMO

Continuous-flow, large-scale production of custom gene amplicons

Production of gram quantities including derivatized DNA

Large amplicons

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Custom robotics available

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cGMP underway

advantages

No bacterial plasmid contaminants

Supports cancer therapy closer to point of care

Rapid, high-purity, adaptable, innovative constructs

Vector-to-linear DNA hyperexpression systems

applications

Partnering available
 

Antibody production 
CAR T cells
 

Antisense RNA and siRNA
 

DNA and RNA Vaccine Production

Engineering of lymphocytes, gene therapy constructs and stem cells

Biomarker-driven cancer gene identification to screen out epitopes