PCR-produced linear DNA

the pure, fast and flexible alternative to plasmids

our technology

LineaRx provides large-scale production of DNA sequences using polymerase chain reaction (PCR). Scaling PCR for high volume delivers highly purified DNA, without the complications of plasmids, for use in cell therapies, vaccines, diagnostics and gene therapies. We can meet CRO and CMO needs with linear DNA at any scale.

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In the past 12 months, LineaRx has shipped over 8,000 milligrams of PCR-produced linear DNA for use in Diagnostic and Therapeutic applications. The Company has completed, or is progressing through, key milestones of a growing number of therapeutics research contracts for companies producing DNA and RNA vaccines and adoptive cell therapies.

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CRO/CMO

Continuous-flow, large-scale production of custom gene amplicons
Production of gram quantities including derivatized DNA
Large amplicons
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Custom robotics available
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cGMP underway
 

advantages

No bacterial plasmid contaminants

 
Supports cancer therapy closer to point of care
 
 
Rapid, high-purity, adaptable, innovative constructs
 
 
Vector-to-linear DNA hyperexpression systems
 
 

applications

Partnering available
 
Antibody production 
CAR T cells
 
Antisense RNA and siRNA
 
DNA and RNA Vaccine Production
Engineering of lymphocytes, gene therapy constructs and stem cells
 
Biomarker-driven cancer gene identification to screen out epitopes

linear DNA questionnaire

Please complete as many of these questions as possible so that we can tailor a specific program to meet your needs.

If you have produced this DNA fragment in the past, please indicate the method (select all that apply):
Can you provide a positive control of your product?
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Please select desired purification level:
Please select quantitation method:
Please select desired scale:

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